Cambridge researchers who study the processes of cellular rejuvenation have reached the first positive results in mice. They believe that we could reduce the biological age of our cells.
Researchers from the Babraham Institute, a scientific organization in Cambridge, have developed a technique for reprogramming skin cells to behave as if they were much younger.
During this experiment, which has just been published in the journal Aging cell , the researchers wanted to improve the ability of aged mice to repair damage to their tissues. Their reprogrammed cells produced more collagen protein, resulting in faster (and scarless) wound healing than mice whose cells had not undergone the reprogramming process.
Furthermore, the kidneys and skin of these mice were identical to those of younger mice, and the scientists did not observe the usual metabolic changes in the blood, as is usually seen in older animals.
“Our understanding of aging at the molecular level has advanced over the past decade. This new experiment represents a major step forward in our understanding of cellular reprogramming,” said Dr Diljeet Gill, researcher at the Babraham Institute.
Source : Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming, Aging cell, avril 2022